Remdesivir (Gilead), an investigational broad-spectrum IV antiviral drug that is active against SARS-CoV-2 and other corona-viruses in vitro and in animal models.
Antibody-Dependent Enhancement occurs when antibodies facilitate viral entry into host cells and enhance viral infection. ADE is found to be associated with a variety of viruses, mostly with flaviviruses. Detailed molecular mechanism for Antibody-Dependent Enhancement of coronavirus entry is still unknown.
The presence of specific microbiota, or microorganisms that live in the digestive tract, can prevent and cure rotavirus infection, which is the leading cause of severe, life-threatening diarrhea in children worldwide, according to a new study.
Mammalian cells contains NAD+-capped mRNAs and degraded by DXO family enzymes and scientists found that 5' end Nicotinamide Adenine Dinucleotide cap in human cells promotes RNA decay through DXO-Mediated deNADding.
Apoptosis studies has mostly focused on protein degradation by the caspases, MOMP and DNA fragmentation but little is known about the fate of RNA. Judy Lieberman discovered new mechanism of RNA decay.
Autoimmune-prone Annexin-A1 transgenic mice show high level of anxiety-like behavior and this was linked to high levels of an anxiogenic protein we christened Immno-moodulin. Antibodies against Immno-moodulin might be the future biologics for mental disorders.
Existing antivirals and knowledge gained from the SARS and MERS outbreaks gain traction as the fastest route to fight the current coronavirus epidemic.